Our research explores how light interacts with micro‑ and nanoscale systems in complex fluid environments. We develop optical and thermal tools to precisely control particle motion and drive rapid fluid flows, revealing fundamental links between light, temperature, and hydrodynamics.
Using synthetic colloids and condensate‑inspired droplets as model systems, we design and study mechanisms of self‑propulsion, self‑assembly, and collective behaviour across multiple length scales. These engineered platforms form the basis for automated assays that probe transport, phase separation, and material state under controlled stress.
A central goal is to transfer these concepts and tools to biological and biomimetic matter. By applying light‑driven control and optofluidic approaches to living cells and protein condensates, we investigate how physical forces shape biological organisation, from stress responses to pathological aggregation.
Our work lies at the interface of optofluidics, soft‑matter physics, and bioengineering, with key focus areas including:
- Light‑driven fluidic systems and automated microenvironments
- Phase separation and material states in biomolecular condensates
- Physics‑informed assays for biotech and drug discovery
We offer Bachelor and Master projects that involve building and using these experimental platforms, and we actively support applications for competitive postdoctoral fellowships for researchers interested in developing new physics‑based tools for biology and biotechnology.
News & Events
Talk by Falko Schmidt at Soft Matter Days, Uni Leipzig
Falko Schmidt is presenting his groups latest work on optothermal manipulation of biomolecular condensates. Title of Talk: Programmable architectures in biomolecular condensates by thermal feedback Time/Date: 09:40 CET/10.07.2026 Place: Uni Leipzi...
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Poster by Ilona Kundis at the DPG Spring Meeting
Master student Ilona Kundi is presenting our recent investigations into thermally controlled liquid-liquid phase separations of biocondensates at the DPG Spring Meeting in Dresden, Germany. Title of Poster: 3D Optofluidic Control Using Reconfigurable...
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Talk by Falko Schmidt at DPG Spring Meeting
Falko Schmidt is presenting a reconfigurable optofluidic platform for the precise manipulation of local fluid flows and particle movement at the DPG Spring Meeting in Dresden, Germany. Title of Talk: 3D Optofluidic Control Using Reconfigurable Therma...
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Research Projects
Light-induced micro and nano machines
Optical tweezers are used to induce rotational motion of nanoparticles and microparticles effectively creating miniaturised versions of macroscopic engines.
Under light illumination a suspension of binary colloids self-assembles into active hierarchical superstructures providing insights into the formation process of biological systems.
3D Optofluidics and Thermal Imaging
The local heating of fluids with light leads to complex pattern of flows that can be steered and measured with light using optofluidics and thermometry.
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Publications
Three-dimensional optofluidic control using reconfigurable thermal barriers
Falko Schmidt, Carlos David Gonzalez-Gomez, Marc Sulliger, Emilio Ruiz-Reina, Raul A. Rica, Jaime Ortega Arroyo, Romain Quidant
Nature Photonics, 2025
Non–steady state thermometry with optical diffraction tomography
Adarsh B Vasista, Bernard Ciraulo, Falko Schmidt, Jaime Ortega Arroyo, Romain Quidant
Science Advances, vol. 10(12), 2024, pp. eadk5440
Nanoalignment by Critical Casimir Torques
Gan Wang, Piotr Nowakowski, Nima Farahmand Bafi, Benjamin Midtvedt, Falko Schmidt, Ruggero Verre, Mikael Käll, S. Dietrich, Svyatoslav Kondrat, Giovanni Volpe
Nature Communications, vol. 15(5086), 2024
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About Me:
He has over 9 years of experience in building holographic optical setups for experiments on the optical manipulation of micro- and nanosystems. He is the author of 7 scientific peer-reviewed articles published in renowned journals (e.g. Nature Physics, Nature Communications, Physical Review Letters, ACS Photonics). He is also the co-founder of Lucero AB, a spin-off from research at the University of Gothenburg developing automated manipulation solutions for single cells in drug screening purposes.